Frequency of dense fine speckled pattern in immunofluorescence screening test
نویسندگان
چکیده
منابع مشابه
Frequency of dense fine speckled pattern in immunofluorescence screening test.
OBJECTIVE The presence of antinuclear antibodies (ANA), directed against intracellular antigens, is a distinctive feature of systemic autoimmune rheumatic diseases (SARDs). The standard test for antinuclear antibody screening is the indirect immunofluorescence (IIF). Anti-dense fine speckled 70 (anti-DFS70) antibodies were initially identified as an ANA IIF pattern from a patient with interstit...
متن کاملLaboratorial significance of autoantibodies of dense fine speckled pattern
Purpose Indirect immunofluorescence (IIF) in Hep-2 cells is the standard screening test for antinuclear antibodies (ANA). Advances in this methodology have brought up a considerable increase in sensitivity and consequently a decrease in its specificity. This has resulted in an increasing number of positive tests in apparently healthy subjects. In particular, autoantibodies associated with the d...
متن کاملThe Clinical Significance of the Dense Fine Speckled Immunofluorescence Pattern on HEp-2 Cells for the Diagnosis of Systemic Autoimmune Diseases
Antinuclear antibodies (ANAs) are a serological hallmark in the diagnosis of systemic autoimmune rheumatic diseases (SARD). The indirect immunofluorescence (IIF) assay on HEp-2 cells is a commonly used test for the detection of ANA and has been recently recommended as the screening test of choice by a task force of the American College of Rheumatology. However, up to 20% of apparently healthy i...
متن کاملClinical relevance and frequency of cytoplasmic and nuclear dense fine speckled patterns observed in ANA-HEp-2.
OBJECTIVES This study aimed to determine the frequency and antibody titers of nuclear dense fine and cytoplasmic patterns with possible clinical correlation. METHODS From 2007 to 2009, the results of 2,788 autoantibody serological tests were assessed by indirect immunofluorescence (IIF) at LAC-HUSM/UFSM, using as substrate HEp-2. RESULTS Among the analyzed samples, 1,998 of them were negati...
متن کاملSingularities in speckled speckle: screening.
We study screening of optical singularities in random optical fields with two widely different length scales. We call the speckle patterns generated by such fields speckled speckle, because the major speckle spots in the pattern are themselves highly speckled. We study combinations of fields whose components exhibit short- and long-range correlations and find unusual forms of screening.
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ژورنال
عنوان ژورنال: European Journal of Rheumatology
سال: 2015
ISSN: 2147-9720,2148-4279
DOI: 10.5152/eurjrheum.2015.0003